The influence of two tuning agents, polyglycerol ester (PE) and triblock copolymer (TC),\non the properties of glycerol monooleate (MO) liquid crystalline phase (LCP) was investigated to\nachieve the therapeutic concentration of vancomycin hydrochloride (VHCl) into the eye, topically\nduring 60 min (1 h) and intravitreally during 2880 min (48 h). Different techniques were used to\nelucidate the impact of surfactants on the structure of the LCP: polarized light microscopy (PLM),\nsmall-angle X-ray scattering (SAXS), and in vitro release tests I and II (simulating local and intravitreal\napplication in the eye). The structure analysis by SAXS depicts that the inclusion of PE into the MO\nLCP provided partial transition of a hexagonal phase into a lamellar phase, and TC induced a partial\ntransition of a hexagonal phase into an LCP which identification was difficult. The LCP modulated\nwith PE and TC demonstrated different VHClâ??s release patterns and were evaluated by comparing\nour release data with the literature data. The comparison indicated that the LCP modulated with 30%\nw/w PE could be a promising VHCl delivery system intravitreally during 2880 min.
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